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Bryan Roth to Speak About Functional Selectivity at GPCR Conference, May 22-23, 2014, Cambridge, MA

Bryan Roth to Speak at GPCR Conference, May 22-23, 2014 in Cambridge, MA
 
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    CAMBRIDGE, MA, January 15, 2014 /24-7PressRelease/ -- Bryan Roth, Professor at UNC Chapel Hill Medical School, will speak about "Structural Insights into GPCR Functional Selectivity" at the GPCR Structure, Function and Drug Discovery Conference, to be held May 22-23, 2014 in Cambridge, MA.

G-protein coupled receptors (GPCRs) represent the single largest target class for therapeutic drug discovery. Recent findings from many labs suggest that drugs which selectively and differentially engage various GPCR down-stream pathways might have unique therapeutic utility. This process is described as functional selectivity and drugs which have this feature are considered to have signaling bias.

Professor Roth will describe recent high resolution GPCR structures that have provided novel insights into the structural requirements responsible for GPCR functional selectivity. For instance, GPCRs exist in a multitude of conformations; these conformations can be selectively engaged by down-stream effectors, including G-proteins and b-arrestins. Dr. Roth will also describe how this information can be utilized for the rational design and testing of biased agonists.

Dr. Roth is a Michael Hooker Distinguished Professor of Pharmacology, Chemical Biology and Medicinal Chemistry at the University of North Carolina Chapel Hill Medical School. He also serves as the director of the NIMH Psychoactive Drug Screening Program. Dr. Roth has published more than 350 papers and has given more than 250 invited talks, mainly in the area of GPCR structure, function and pharmacology.

For more information about the conference, please visit http://www.gtcbio.com/gpcr.



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