/24-7PressRelease/ - GAITHERSBURG, MD, June 06, 2008 - Many scientists are converting from growing cells in a traditional 2-D Monolayer on plastic surfaces with tissue culture medium to 3-D Culture. In 3-D Culture, cells are grown in a microenvironment of specialized proteins which mimics in vivo conditions and allows the cells to organize into complex structures rather than uniform monolayers. Various types of cells require different specialized proteins for optimal growth conditions and these extracellular matrices can play an important role in modulating cellular response to pharmacological compounds. For these reasons, conversion to 3-D culture with different matrices is highly desirable, but until now there has not been a practical way to evaluate cell proliferation from 3-D cultures.
Trevigen has an innovative solution with the introduction of four new 3-D cell proliferation kits including a core kit and three different kits containing basement membrane extract, laminin I, and collagen I. These are the first standardized kits engineered for assessing the effects of compounds or genetic alteration on cell proliferation in 3-D culture. The high throughput 96 stripwell formats allow one step quantitative analysis and colorimetric detection. Protocols are provided for tumorgenicity and cytotoxicity.
Trevigen, Inc. is a rapidly growing biotechnology company focused on the development of products and technology for cancer research, emphasizing apoptosis, DNA damage and repair, and cancer cell function and behavior. Trevigen has been a long-standing provider of quality reagents and kits for researchers investigating programmed cell death and DNA damage and repair. A logical extension of the focus on cancer research has been the recent development of assays for cancer cell function and behavior including angiogenesis, cell invasion and tumor formation. Currently, the product portfolio contains over 500 products categorized into four processes " Apoptosis, DNA Damage and Repair, Angiogenesis, and Oxidative Stress. 3-D qualified BME, Laminin I and Collagen I are also available separately from Trevigen. Visit http://www.trevigen.com or contact us at 1800-873-8443 or info@trevigen.com for more information.
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- angiongenesis, biology, biotech, bme, cancer, cell, culture, matrigel, proliferation, research, trevigen
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