TUCSON, AZ, June 04, 2020 /24-7PressRelease/ -- Marquis Who's Who, the world's premier publisher of biographical profiles, is proud to present Mohammad Shahidullah with the Albert Nelson Marquis Lifetime Achievement Award. An accomplished listee, Dr. Shahidullah celebrates many years' experience in his professional network, and has been noted for achievements, leadership qualities, and the credentials and successes he has accrued in his field. As in all Marquis Who's Who biographical volumes, individuals profiled are selected on the basis of current reference value. Factors such as position, noteworthy accomplishments, visibility, and prominence in a field are all taken into account during the selection process.
Having accrued more than 35 years of experience in his field of research, Dr. Shahidullah has garnered a laudable reputation as an associate professor of ophthalmology and physiology on behalf of the University of Arizona since 2006. Beginning his career in academia in 1983 as a lecturer and assistant professor of pharmacology in his home country at the Bangladesh Agricultural University in Mymensingh, he subsequently contributed for seven years as a postdoctoral research fellow at the University of Glasgow in Scotland until 2001 and another four years as a research fellow and lecturer at Hong Kong Polytechnic University in Kowloon until 2005. Moving to the U.S., Dr. Shahidullah was acquired by the University of Louisville, where he contributed for an additional year as an assistant professor.
As a medical researcher, Dr. Shahidullah has been responsible for a number of seminal discoveries in his field of aqueous humor secretion and lens physiology. The most notable discoveries are: (1) development of arterially perfused eye preparation and primary culture of nonpigmented ciliary epithelium (NPE) and lens epithelium. These experimental platforms played pivotal roles in his discoveries and in studying many aspects of ocular physiology and pharmacology, including retinal electrophysiology, signal transduction mechanisms involved in ion transport, aqueous humor secretion and drug transport by the NPE, and ion transport functions of the lens. (2) Discovery that Src tyrosine kinases regulate Na,K-ATPase activity in the NPE and in the lens epithelium. He is the pioneer in showing how receptors, and Src family tyrosine kinases interact to regulate Na,K-ATPase activity. Additionally, he showed how activation of certain G protein-coupled receptors speeds up active Na-K transport while different receptors slow down the process. Different receptors appear to couple to different tyrosine kinase members of the Src family (SFKs). (3) Discovery of a role for transient receptor potential vanilloid 4 (TRPV4). Here he discovered a novel TRPV4 channel-dependent mechanism for SFK activation in the lens epithelium. This discovery enabled scientists to understand how TRPV4 activates a feedback loop mechanism that includes hemichannel opening, ATP release, and a cAMP increase, all of which lead eventually to SFK activation and increased Na,K-ATPase activity. (4) Discovery of interaction between TRPV4 and connexin 50 hemichannels that constitute a unique remote-control signaling mechanism in the lens. He showed that injury to a remote area of the lens fiber mass or changes in hydrostatic pressure (HP) of lens cells can initiate a signaling response in the surface epithelium. In structural context of the lens, the epithelial cells have specialized to make TRPV4 channel a critical component of the remote control mechanism to influence Na,K-ATPase activity. (5) Discovery of two independently operated sense and respond feedback control systems that maintain normal hydrostatic pressure or ion/water or volume homeostasis of the lens. One feedback control system is sensed by TRPV4 in response to swelling (increased volume) or increased HP of the lens initiating a multicomponent signaling mechanism that ultimately activate Na,K-ATPase. Activation of Na,K-ATPase in turn helps the lens returning to its normal volume or hydrostatic pressure. The other feedback control system is sensed by TRPV1 in response to lens shrinkage (decreased volume) or decreased HP of the lens cells initiating a multicomponent signaling mechanism that ultimately activate Sodium-Potassium-Chloride Cotransporter 1 (NKCC1). Activation of NKCC1 in turn helps the lens returning to its normal volume or hydrostatic pressure. His discoveries are published in many high impact scientific journals, including, British Journal of Pharmacology, European Journal of Pharmacology, American Journal of Physiology, Journal of Cellular Physiology, The Journal of Pharmacology and Experimental Therapeutics, Molecular Pharmacology, Drug Metabolism and Disposition, PLoS One, Gut, Endocrinology, Brain Research, Investigative Ophthalmology and Visual Science and Experimental Eye Research.
Dr. Shahidullah received a Doctor of Veterinary Medicine at Bangladesh Agricultural University in 1982. He also earned distinction as a merit scholar on campus between 1977 and 1983. Dr. Shahidullah later attained a Doctor of Philosophy at the University of Glasgow in 1994. Among his professional memberships, Dr. Shahidullah is aligned with the American Physiological Society, the International Society for Eye Research, the Federation of Bangladesh University Teachers Association, the Association of University Teachers in the United Kingdom and the Association for Research in Vision and Ophthalmology.
Dr. Shahidullah was recognized as a Commonwealth scholar at the Association of Commonwealth Universities in the United Kingdom during 1990. He notably received several awards during his career, including a University Prize from his alma mater, Bangladesh Agricultural University, in 1985 and a Research Louisville Award in 2005. A celebrated Marquis listee, Dr. Shahidullah has been featured in close to 30 editions of Who's Who in America, Who's Who in Medicine and Healthcare, Who's Who in Science and Engineering and Who's Who in the World.
Dr. Shahidullah is married to Sadequn Nahar who is a Physics teacher at Sunnyside High School, Tucson, Arizona. The couple has two sons, the elder one, Asif Shahidullah, is an electrical engineer and the younger son, Archie Shahidullah, is a sophomore in Computer Science at the California Institute of Technology. Office: Department of Physiology, College of Medicine, University of Arizona, Tucson, 1501 N Campbell Ave., AZ 85724. Phone: 520 626 7351 (O), 520 576 3732 (C), Fax: 520 626 2382, E-mail: [email protected].
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